Important Safety Considerations of Restylane® and Perlane®

Either Restylane® or Perlane® can be used to restore volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds), ask your physician which is right for you. After your treatment, you might have some swelling, redness, pain, bruising, and tenderness. This will normally last less than seven days. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause another outbreak. In rare circumstances, the doctor may inject into a blood vessel, which can damage the skin. To avoid bruising and bleeding, you should not use either product if you have recently used drugs that thin your blood or prevent clotting. if you are pregnant, breastfeeding, or under 18 years, you should not use Restylane® or Perlane®.

Restylane® or Perlane® should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram-positive bacteria; by people with previous bad allergies to drugs that have requird in-hospital treatment; or by people with bleeding disorders. Injections should not be made anywhere except the skin or just under the skin.

Patients should be limited to 6.0 mL per treatment. The safety or effectiveness of Restylane® and Perlane® for the treatment of anatomic regions other than nasolabial folds have not been established in controlled clinical studies.

The use of Restylane® or Perlane® at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. Use of either product in these instances could delay healing or make your skin problems worse.

Restylane® and Perlane® are available only through a licensed practitioner. Complete product
and safety information is available at www.RestylaneUSA.com.

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